Principles of Clinical Pharmacology - Edition 2 - Edited by Arthur J. Atkinson, Jr., Darrell R. Abernethy, Charles E. Daniels, Robert Dedrick and Sanford P. Markey Elsevier Educate

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Principles of Clinical Pharmacology,

Edition 2

Edited by Arthur J. Atkinson, Jr., Darrell R. Abernethy, Charles E. Daniels, Robert Dedrick and Sanford P. Markey

Publication Date: 20 Sep 2006

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This revised second edition covers the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development, focusing on the fundamentals that underlie the clinical use and contemporary development of pharmaceuticals. Authors drawn from academia, the pharmaceutical industry and government agencies cover the spectrum of material, including pharmacokinetic practice questions, covered by the basic science section of the certifying examination offered by the American Board of Clinical Pharmacology. This unique reference is recommended by the Board as a study text and includes modules on drug discovery and development to assist students as well as practicing pharmacologists.

Key Features

Unique breadth of coverage ranging from drug discovery and development to individualization and quality assessment of drug therapy
Unusual cohesive of presentation that stems from author participation in an ongoing popular NIH course
Instructive linkage of pharmacokinetic theory and applications with provision of sample problems for self-study
Wide-ranging perspective of authors drawn from the ranks of Federal agencies, academia and the pharmaceutical industry
Expanded coverage of pharmacogenetics
Expanded coverage of drug transporters and their role in interactions
Inclusion of new material on enzyme induction mechanisms in chapters on drug metabolism and drug interactions
A new chapter on drug discovery that focuses on oncologic agents
Inclusion of therapeutic antibodies in chapter on biotechnology products

About the author

Edited by Arthur J. Atkinson, Jr., Northwestern University, Chicago, Illinois , U.S.A.; Darrell R. Abernethy, National Institute on Aging, Baltimore, Maryland, U.S.A.; Charles E. Daniels, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA; Robert Dedrick, National Institute of Health, Bethesda, Maryland, U.S.A. and Sanford P. Markey, National Institute of Mental Health, Bethesda, Maryland, U.S.A.

1. Introduction

PART 1: PHARMACOKINETICS
2. Clinical pharmacokinetics
3. Compartmental analysis of drug distribution
4. Drug absorption and bioavailability
5. Effects of renal disease on pharmacokinetics
6. Kinetics of hemodialysis and hemofiltration
7. Effects of liver disease on pharmacokinetics
8. Noncompartmental vs. compartmental approaches to pharmacokinetic analysis
9. Distributed models of drug kinetics
10. Population pharmacokinetics

PART 2: DRUG METABOLISM AND TRANSPORT
11. Pathways of drug metabolism
12. Biochemical mechanisms of drug toxicity
13. Chemical assay of drugs and drug metabolites
14. Equilibrative and concentrative transport
15. Pharmacogenetics
16. Drug interactions

PART 3: ASSESSMENT OF DRUG EFFECTS
17. Physiological and laboratory markers of drug effect
18. Dose response and concentration response analysis
19. Kinetics of pharmacologic effect
20. Disease progression models

PART 4: OPTIMIZING AND EVALUATING PATIENT THERAPY
21. Sex differences in pharmacokinetics and pharmacodynamics
22. Drug therapy in pregnant and nursing women
23. Drug therapy in neonates and pediatric patients
24. Drug therapy in the elderly
25. Clinical analysis of adverse drug reactions
26. Quality assessment of drug therapy

PART 5: DRUG DISCOVERY AND DEVELOPMENT
27. Project management
28. Drug discovery
29. Pre-clinical development
30. Animal scale up
31. Phase I studies
32. PK and PD considerations in the development of biotechnology products and large molecules
33. Design of clinical development programs
34. Good design practices for clinical trials
35. Role of the FDA in guiding drug development

Appendix
I. Table of Laplace Transforms
II. Answers to Study Problems

ISBN: 9780123694171

Page Count: 568

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Atkinson, Jr. et al: Principles of Clinical Pharmacology (Aug 2001, ISBN-10/13: 0-12-066060-1/ 978-0-12-066060-5)
Gallin: Principles and Practice of Clinical Research (Jan 2002, ISBN-10/13: 0-12-274065-3/ 978-0-12-274065-7)
Ahuja and Scypinski: Handbook of Modern Pharmaceutical Analysis (Jul 2001, ISBN-10/13: 0-12-045555-2/ 978-0-12-045555-3)

Clinical pharmacologists, pharmacologists, clinicians, pharmaceutical industry and government regulatory agencies

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