Molecular Pathology,
Edition 1
The Molecular Basis of Human Disease
Edited by William B. Coleman and Gregory J. Tsongalis
Publication Date:
02 Mar 2009
Description
Molecular Pathology: The Molecular Basis of Human Disease provides a current and comprehensive view of the molecular basis and mechanisms of human disease. Combining accepted principles with broader theoretical concepts and with contributions from a group of experts, the book looks into disease processes in the context of traditional pathology and their implications for translational molecular medicine. It also discusses concepts in molecular biology and genetics, recent scientific and technological advances in modern pathology, the concept of ""molecular pathogenesis"" of disease, and how disease evolves from normal cells and tissues due to perturbations in molecular pathways.
The book describes the integration of molecular and cellular pathogenesis using a bioinformatics approach and a systems biology approach to disease pathogenesis. It also discusses current and future strategies in molecular diagnosis of human disease, and the impact of molecular diagnosis on treatment decisions and the practice of personalized medicine.
This book is a valuable resource for students, biomedical researchers, practicing physician-scientists who undertake disease-related basic science and translational research, and pathology residents and other postdoctoral fellows.
Key Features
- Exam Master® web site will host "Self-assessment" questions that students can use to study for the molecular section of the board exam
- Teaches from the perspective of “integrative systems biology,¿ which encompasses the intersection of all molecular aspects of biology, as applied to understanding human disease
- Outlines the principles and practice of molecular pathology
- Explains the practice of “molecular medicine¿ and the translational aspects of molecular pathology
About the author
Edited by William B. Coleman, PhD, Professor, Department of Pathology and Laboratory Medicine, Curriculum in Toxicology, Program in Translational Medicine, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA and Gregory J. Tsongalis, PhD, Professor of Pathology and Laboratory Medicine, Director of Laboratory for Clinical Genomics and Advanced Technology (CGAT), Audrey and Theodor Geisel School of Medicine at Dartmouth, Dartmouth-Hitchcock Medical Center and Norris Cotton Cancer Center, Lebanon, NH, USA
Table of Contents
List of Contributors
Preface
Foreword
Acknowledgments
Part I Essential Pathology – Mechanisms of Disease
Chapter 1 Molecular Mechanisms of Cell Death
Introduction
Modes of Cell Death
Structural Features of Necrosis and Apoptosis
Cellular and Molecular Mechanisms Underlying Necrotic Cell Death
Pathways to Apoptosis
Mitochondria
Nucleus
Endoplasmic Reticulum
Lysosomes
Concluding Remark
Chapter 2 Acute and Chronic Inflammation Induces Disease Pathogenesis
Introduction
Leukocyte Adhesion, Migration, and Activation
Acute Inflammation and Disease Pathogenesis
Pattern Recognition Receptors and Inflammatory Responses
Chronic Inflammation and Acquired Immune Responses
Tissue Remodeling During Acute and Chronic Inflammatory Disease
Chapter 3 Infection and Host Response
Microbes and Hosts—Balance of Power?
The Structure of the Immune Response
Regulation of Immunity
Pathogen Strategies
The African Trypanosome and Antibody Diversity: Dueling Genomes
Staphylococcus Aureus: the Extracellular Battleground
Mycobacterium Tuberculosis and the Macrophage
Herpes Simplex Virus: Taking Over
HIV: The Immune Guerilla
Perspectives
Chapter 4 Neoplasia
Introduction
Cancer Statistics and Epidemiology
Classification of Neoplastic Diseases
Characteristics of Benign and Malignant Neoplasms
Clinical Aspects of Neoplasia
Part II Concepts in Molecular Biology and Genetics
Chapter 5 Basic Concepts in Human Molecular Genetics
Introduction
Molecular Structure of DNA, DNA Transcription, and Protein Translation
Molecular Pathology and DNA Repair Mechanisms
Modes of Inheritance
Central Dogma and Rationale for Genetic Testing
Allelic Heterogeneity and Choice of Analytical Methodology
Conclusion
Chapter 6 The Human Genome: Implications for the Understanding of Human Disease
Introduction
Structure and Organization of the Human Genome
Overview of the Human Genome Project
Impact of the Human Genome Project on the Identification of Disease-Related Genes
Sources of Variation in the Human Genome
Types of Genetic Diseases
Genetic Diseases and Cancer
Perspectives
Chapter 7 The Human Transcriptome: Implications for the Understanding of Human Disease
Introduction
Gene Expression Profiling: The Search for Candidate
Genes Involved in Pathogenesis
Transcriptome Analysis Based on Microarrays: Technical Prerequisites
Microarrays: Bioinformatic Analysis
Microarrays: Applications in Basic Research and Translational Medicine Perspectives
Chapter 8 The Human Epigenome: Implications for the Understanding of Human Disease
Introduction
Epigenetic Regulation of the Genome
Genomic Imprinting
Cancer Epigenetics
Human Disorders Associated with Epigenetics
Environment and the Epigenome
Chapter 9 Clinical Proteomics and Molecular Pathology
Understanding Cancer at the Molecular Level: An Evolving Frontier
Microdissection Technology Brings Molecular Analysis to the Tissue Level
Serum Proteomics: An Emerging Landscape for Early Stage Cancer Detection
Chapter 10 Integrative Systems Biology: Implications for the Understanding of Human Disease
Introduction
Data Generation
Data Integration
Modeling Systems
Implications for Understanding Disease
Discussion
Part III Principles and Practice of Molecular Pathology
Chapter 11 Pathology: The Clinical Description of Human Disease
Introduction
Terms, Definitions, and Concepts
A Brief History of Approaches to Disease
Current Practice of Pathology
The Future of Diagnostic Pathology
Conclusion
Chapter 12 Understanding Molecular Pathogenesis: The Biological Basis of Human Disease and Implications for Improved Treatment of Human Disease
Introduction
Hepatitis C Virus Infection
Acute Myeloid Leukemia
Cystic Fibrosis
Chapter 13 Integration of Molecular and Cellular Pathogenesis: A Bioinformatics
Approach
Introduction
Overview of Bioinformatics
Database Resources
Data Analysis
The Future of Bioinformatics
Chapter 14 Molecular Basis of Cardiovascular Disease
Introduction
General Molecular Principles of Cardiovascular
Diseases
The Cells of Cardiovascular Organs
Atherosclerosis
Ischemic Heart Disease
Aneurysms
Vasculitis
Valvular Heart Disease
Cardiomyopathies
Chapter 15 Molecular Basis of Hemostatic and Thrombotic Diseases
Introduction and Overview of Coagulation
Disorders of Soluble Clotting Factors
Disorders of Fibrinolysis
Disorders of Platelet Number or Function
Thrombophilia
Chapter 16 Molecular Basis of Lymphoid and Myeloid Diseases
Development of the Blood and Lymphoid Organs
Myeloid Disorders
Lymphocyte Disorders
Chapter 17 Molecular Basis of Diseases of Immunity
Introduction
Normal Immune System
Major Syndromes
Chapter 18 Molecular Basis of Pulmonary Disease
Introduction
Neoplastic Lung and Pleural Diseases
Non-neoplastic Lung Disease
Obstructive Lung Diseases
Interstitial Lung Diseases
Pulmonary Vascular Diseases
Pulmonary Infections
Pulmonary Histiocytic Diseases
Pulmonary Occupational Diseases
Developmental Abnormalities
Chapter 19 Molecular Basis of Diseases of the Gastrointestinal Tract
Introduction
Gastric Cancer
Colorectal Cancer
Chapter 20 Molecular Basis of Liver Disease
Introduction
Molecular Basis of Liver Development
Molecular Basis of Liver Regeneration
Adult Liver Stem Cells in Liver Health and Disease
Molecular Basis of Hepatocyte Death
Molecular Basis of Nonalcoholic Fatty Liver Disease
Molecular Basis of Alcoholic Liver Disease
Molecular Basis of Hepatic Fibrosis and Cirrhosis
Molecular Basis of Hepatic Tumors
Chapter 21 Molecular Basis of Diseases of the Exocrine Pancreas
Acute Pancreatitis
Chronic and Hereditary Pancreatitis
Summary
Chapter 22 Molecular Basis of Diseases of the Endocrine System
Introduction
The Pituitary Gland
The Thyroid Gland
The Parathyroid Gland
The Adrenal Gland
Puberty
Chapter 23 Molecular Basis of Gynecologic Diseases
Introduction
Benign and Malignant Tumors of the Female
Reproductive Tract
Disorders Related to Pregnancy
Chapter 24 Molecular Pathogenesis of Prostate Cancer: Somatic, Epigenetic, and Genetic Alterations
Introduction
Hereditary Component of Prostate Cancer Risk
Somatic Alterations in Gene Expression
Epigenetics
Advances in Mouse Models of Prostate Cancer
Conclusion
Acknowledgments
Chapter 25 Molecular Biology of Breast Cancer
Introduction
Traditional Breast Cancer Classification
Biomarkers
Gene Expression Profiling
Conclusion
Chapter 26 Molecular Basis of Skin Disease
Introduction
Skin Diseases and Their Impact
Molecular Basis of Healthy Skin
Skin Development and Maintenance Provide New Insight into the Molecular Mechanisms of Disease
Molecular Pathology of Mendelian Genetic Skin Disorders
Molecular Pathology of Common Inflammatory Skin Diseases
Skin Proteins as Targets for Inherited and Acquired Disorders
Molecular Pathology of Skin Cancer
Molecular Diagnosis of Skin Disease
New Molecular Mechanisms and Novel Therapies
Chapter 27 Molecular Pathology: Neuropathology
Anatomy of the Central Nervous System
Neurodevelopmental Disorders
Neurological Injury: Stroke, Neurodegeneration, and Toxicants
Neoplasia
Disorders of Myelin
Part V Practice of Molecular Medicine
Chapter 28 Molecular Diagnosis of Human Disease
Introduction
History of Molecular Diagnostics
Molecular Laboratory Subspecialties
Future Applications
Chapter 29 Molecular Assessment of Human Disease in the Clinical Laboratory
Introduction
The Current Molecular Infectious Disease Paradigm
A New Paradigm for Molecular Diagnostic Applications
BCR-ABL: A Model for the New Paradigm
Conclusion
Chapter 30 Pharmacogenomics and Personalized Medicine in the Treatment of Human
Diseases
Introduction
Conclusion
Index
List of Contributors
Preface
Foreword
Acknowledgments
Part I Essential Pathology – Mechanisms of Disease
Chapter 1 Molecular Mechanisms of Cell Death
Introduction
Modes of Cell Death
Structural Features of Necrosis and Apoptosis
Cellular and Molecular Mechanisms Underlying Necrotic Cell Death
Pathways to Apoptosis
Mitochondria
Nucleus
Endoplasmic Reticulum
Lysosomes
Concluding Remark
Chapter 2 Acute and Chronic Inflammation Induces Disease Pathogenesis
Introduction
Leukocyte Adhesion, Migration, and Activation
Acute Inflammation and Disease Pathogenesis
Pattern Recognition Receptors and Inflammatory Responses
Chronic Inflammation and Acquired Immune Responses
Tissue Remodeling During Acute and Chronic Inflammatory Disease
Chapter 3 Infection and Host Response
Microbes and Hosts—Balance of Power?
The Structure of the Immune Response
Regulation of Immunity
Pathogen Strategies
The African Trypanosome and Antibody Diversity: Dueling Genomes
Staphylococcus Aureus: the Extracellular Battleground
Mycobacterium Tuberculosis and the Macrophage
Herpes Simplex Virus: Taking Over
HIV: The Immune Guerilla
Perspectives
Chapter 4 Neoplasia
Introduction
Cancer Statistics and Epidemiology
Classification of Neoplastic Diseases
Characteristics of Benign and Malignant Neoplasms
Clinical Aspects of Neoplasia
Part II Concepts in Molecular Biology and Genetics
Chapter 5 Basic Concepts in Human Molecular Genetics
Introduction
Molecular Structure of DNA, DNA Transcription, and Protein Translation
Molecular Pathology and DNA Repair Mechanisms
Modes of Inheritance
Central Dogma and Rationale for Genetic Testing
Allelic Heterogeneity and Choice of Analytical Methodology
Conclusion
Chapter 6 The Human Genome: Implications for the Understanding of Human Disease
Introduction
Structure and Organization of the Human Genome
Overview of the Human Genome Project
Impact of the Human Genome Project on the Identification of Disease-Related Genes
Sources of Variation in the Human Genome
Types of Genetic Diseases
Genetic Diseases and Cancer
Perspectives
Chapter 7 The Human Transcriptome: Implications for the Understanding of Human Disease
Introduction
Gene Expression Profiling: The Search for Candidate
Genes Involved in Pathogenesis
Transcriptome Analysis Based on Microarrays: Technical Prerequisites
Microarrays: Bioinformatic Analysis
Microarrays: Applications in Basic Research and Translational Medicine Perspectives
Chapter 8 The Human Epigenome: Implications for the Understanding of Human Disease
Introduction
Epigenetic Regulation of the Genome
Genomic Imprinting
Cancer Epigenetics
Human Disorders Associated with Epigenetics
Environment and the Epigenome
Chapter 9 Clinical Proteomics and Molecular Pathology
Understanding Cancer at the Molecular Level: An Evolving Frontier
Microdissection Technology Brings Molecular Analysis to the Tissue Level
Serum Proteomics: An Emerging Landscape for Early Stage Cancer Detection
Chapter 10 Integrative Systems Biology: Implications for the Understanding of Human Disease
Introduction
Data Generation
Data Integration
Modeling Systems
Implications for Understanding Disease
Discussion
Part III Principles and Practice of Molecular Pathology
Chapter 11 Pathology: The Clinical Description of Human Disease
Introduction
Terms, Definitions, and Concepts
A Brief History of Approaches to Disease
Current Practice of Pathology
The Future of Diagnostic Pathology
Conclusion
Chapter 12 Understanding Molecular Pathogenesis: The Biological Basis of Human Disease and Implications for Improved Treatment of Human Disease
Introduction
Hepatitis C Virus Infection
Acute Myeloid Leukemia
Cystic Fibrosis
Chapter 13 Integration of Molecular and Cellular Pathogenesis: A Bioinformatics
Approach
Introduction
Overview of Bioinformatics
Database Resources
Data Analysis
The Future of Bioinformatics
Chapter 14 Molecular Basis of Cardiovascular Disease
Introduction
General Molecular Principles of Cardiovascular
Diseases
The Cells of Cardiovascular Organs
Atherosclerosis
Ischemic Heart Disease
Aneurysms
Vasculitis
Valvular Heart Disease
Cardiomyopathies
Chapter 15 Molecular Basis of Hemostatic and Thrombotic Diseases
Introduction and Overview of Coagulation
Disorders of Soluble Clotting Factors
Disorders of Fibrinolysis
Disorders of Platelet Number or Function
Thrombophilia
Chapter 16 Molecular Basis of Lymphoid and Myeloid Diseases
Development of the Blood and Lymphoid Organs
Myeloid Disorders
Lymphocyte Disorders
Chapter 17 Molecular Basis of Diseases of Immunity
Introduction
Normal Immune System
Major Syndromes
Chapter 18 Molecular Basis of Pulmonary Disease
Introduction
Neoplastic Lung and Pleural Diseases
Non-neoplastic Lung Disease
Obstructive Lung Diseases
Interstitial Lung Diseases
Pulmonary Vascular Diseases
Pulmonary Infections
Pulmonary Histiocytic Diseases
Pulmonary Occupational Diseases
Developmental Abnormalities
Chapter 19 Molecular Basis of Diseases of the Gastrointestinal Tract
Introduction
Gastric Cancer
Colorectal Cancer
Chapter 20 Molecular Basis of Liver Disease
Introduction
Molecular Basis of Liver Development
Molecular Basis of Liver Regeneration
Adult Liver Stem Cells in Liver Health and Disease
Molecular Basis of Hepatocyte Death
Molecular Basis of Nonalcoholic Fatty Liver Disease
Molecular Basis of Alcoholic Liver Disease
Molecular Basis of Hepatic Fibrosis and Cirrhosis
Molecular Basis of Hepatic Tumors
Chapter 21 Molecular Basis of Diseases of the Exocrine Pancreas
Acute Pancreatitis
Chronic and Hereditary Pancreatitis
Summary
Chapter 22 Molecular Basis of Diseases of the Endocrine System
Introduction
The Pituitary Gland
The Thyroid Gland
The Parathyroid Gland
The Adrenal Gland
Puberty
Chapter 23 Molecular Basis of Gynecologic Diseases
Introduction
Benign and Malignant Tumors of the Female
Reproductive Tract
Disorders Related to Pregnancy
Chapter 24 Molecular Pathogenesis of Prostate Cancer: Somatic, Epigenetic, and Genetic Alterations
Introduction
Hereditary Component of Prostate Cancer Risk
Somatic Alterations in Gene Expression
Epigenetics
Advances in Mouse Models of Prostate Cancer
Conclusion
Acknowledgments
Chapter 25 Molecular Biology of Breast Cancer
Introduction
Traditional Breast Cancer Classification
Biomarkers
Gene Expression Profiling
Conclusion
Chapter 26 Molecular Basis of Skin Disease
Introduction
Skin Diseases and Their Impact
Molecular Basis of Healthy Skin
Skin Development and Maintenance Provide New Insight into the Molecular Mechanisms of Disease
Molecular Pathology of Mendelian Genetic Skin Disorders
Molecular Pathology of Common Inflammatory Skin Diseases
Skin Proteins as Targets for Inherited and Acquired Disorders
Molecular Pathology of Skin Cancer
Molecular Diagnosis of Skin Disease
New Molecular Mechanisms and Novel Therapies
Chapter 27 Molecular Pathology: Neuropathology
Anatomy of the Central Nervous System
Neurodevelopmental Disorders
Neurological Injury: Stroke, Neurodegeneration, and Toxicants
Neoplasia
Disorders of Myelin
Part V Practice of Molecular Medicine
Chapter 28 Molecular Diagnosis of Human Disease
Introduction
History of Molecular Diagnostics
Molecular Laboratory Subspecialties
Future Applications
Chapter 29 Molecular Assessment of Human Disease in the Clinical Laboratory
Introduction
The Current Molecular Infectious Disease Paradigm
A New Paradigm for Molecular Diagnostic Applications
BCR-ABL: A Model for the New Paradigm
Conclusion
Chapter 30 Pharmacogenomics and Personalized Medicine in the Treatment of Human
Diseases
Introduction
Conclusion
Index
Book details
ISBN:
9780123744197
Page Count: 664
Retail Price
:
£68.99
Kumar, Robbins' Basic Pathology, 8e (2007, Saunders, 960 pp., $82.95, ISBN: 9781416029731)
Patrinos/Ansorge, Molecular Diagnostics (2005, AP, 488 pp., $104.00, ISBN: 9780125466615)
Naeim, et.al., Hematopathology (2008, AP, 800 pp., $149.95, ISBN: 9780123706072)
Patrinos/Ansorge, Molecular Diagnostics (2005, AP, 488 pp., $104.00, ISBN: 9780125466615)
Naeim, et.al., Hematopathology (2008, AP, 800 pp., $149.95, ISBN: 9780123706072)
Audience
Medical students, pathology graduate students, biomedical graduate students, and some allied health students.
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