Handbook of the Biology of Aging,
Edition 7
Edited by Edward J. Masoro and Steven N. Austad

Publication Date: 16 Nov 2010
Description
Handbook of the Biology of Aging, Seventh Edition, reviews and synthesizes recent findings and discoveries in the field. This volume is part of The Handbooks of Aging series, which also includes The Handbook of the Psychology of Aging and The Handbook of Aging and the Social Sciences. The book is organized into two parts. Part 1 covers basic aging processes. It covers concepts relevant to clinical research, such as muscle, adipose tissue, and stem cells. It discusses research on how dietary restriction can slow down the aging process and extend life in a wide range of species. Part 2 deals with the medical physiology of aging. It contains several chapters on the aging of the human brain. These chapters deal not only with diseases but also with normal aging changes to cerebral vasculature and myelination as well as the clinical implications of those changes. Additional chapters cover how aging affects central features of human health such as insulin secretion, pulmonary and cardiac function, and the ability to maintain body weight and body temperature. The volume is primarily directed at basic researchers who wish to keep abreast of new research outside their own subdiscipline. It will also be useful to medical, behavioral, and social gerontologists who want to learn about the discoveries of basic scientists and clinicians.

Key Features

  • Contains basic aging processes as determined by animal research as well as medical physiology of aging as known in humans
  • Covers hot areas of research, like stem cells, integrated with longstanding areas of interest in aging like telomeres, mitochondrial function, etc.
  • Edited by one of the fathers of gerontology (Masoro) and contributors represent top scholars in gerintology
About the author
Edited by Edward J. Masoro, University of Texas, San Antonio, U.S.A. and Steven N. Austad, University of Texas Health Science Center, San Antonio, TX, USA
Table of Contents

Contributors

Foreword

Preface

About the Editors

Part 1: Basic Aging Processes

1. The Genetic Network of Life-Span Extension by Dietary Restriction

2. Role of the Somatotropic Axis in Mammalian Aging

3. Mechanisms of Mitochondrial Free Radical Production and their Relationship to the Aging Process

4. Aging and Apoptosis in Muscle

5. Aging and Adipose Tissue

6. Aging of Stem Cells: Intrinsic Changes and Environmental Influences

7. Leukocyte Telomere Dynamics, Human Aging, and Life Span

8. An Objective Appraisal of the Free Radical Theory of Aging

9. TOR: A Conserved Nutrient-Sensing Pathway that Determines Life-Span Across Species

10. Comparative Genetics of Aging

11. Sirtuins in Aging and Age-Related Diseases

12. Inflammation in Aging Processes: An Integrative and Ecological Perspective

13. Protein Homeostasis and Aging

Part 2: Medical Physiology of Aging

14. Terminal Weight Loss, Frailty, and Mortality

15. Human Brain Myelination Trajectories Across the Life Span: Implications for CNS Function and Dysfunction

16. Aging and the Cerebral Microvasculature: Clinical Implications and Potential Therapeutic Interventions

17. Aging and Insulin Secretion

18. Cardiovascular Effects of Aging in Primates—Gender Differences

19. Cerebral Vascular Dysfunction with Aging

20. Pulmonary Function in Aging Humans

21. Calorie Restriction in Nonhuman and Human Primates

22. Age-Related Changes in Thermoreception and Thermoregulation

23. Sex Differences in Longevity and Aging

Author Index

Subject Index






Book details
ISBN: 9780123786388
Page Count: 520
Retail Price : £72.99

Binstock and George, Handbook of Aging and the Social Sciences, 6e, 544 pages, 7 x 10, 2005, $79.95, 978-0-12-088388-2

Birren and Schaie, Handbook of the Psychology of Aging, 6e PB & CB, 570 pages, 7 x 10, 2005, $66.95pb & $136cb, 978-0-12-101265-6

Masoro and Austad, Handbook of the Biology of Aging, 6e, 680 pages, 7 x 10, 2005, $99.95, 978-0-12-088387-5

Audience
Researchers in gerontology, developmental psychology, social psychology, and sociology.