Advanced Topics in Forensic DNA Typing: Interpretation - Edition 1 - By John M. Butler, Ph.D. (Analytical Chemistry), University of Virginia Elsevier Inspection Copies

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Advanced Topics in Forensic DNA Typing: Interpretation,

Edition 1

By John M. Butler, Ph.D. (Analytical Chemistry), University of Virginia

Publication Date: 08 Oct 2014

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Advanced Topics in Forensic DNA Typing: Interpretation builds upon the previous two editions of John Butler’s internationally acclaimed Forensic DNA Typing textbook with forensic DNA analysts as its primary audience. Intended as a third-edition companion to the Fundamentals of Forensic DNA Typing volume published in 2010 and Advanced Topics in Forensic DNA Typing: Methodology published in 2012, this book contains 16 chapters with 4 appendices providing up-to-date coverage of essential topics in this important field. Over 80 % of the content of this book is new compared to previous editions.

Key Features

Provides forensic DNA analysts coverage of the crucial topic of DNA mixture interpretation and statistical analysis of DNA evidence
Worked mixture examples illustrate the impact of different statistical approaches for reporting results
Includes allele frequencies for 24 commonly used autosomal STR loci, the revised Quality Assurance Standards which went into effect September 2011

About the author

By John M. Butler, Ph.D. (Analytical Chemistry), University of Virginia, National Institute of Standards and Technology (NIST), Gaithersburg, MD, USA

Table of Contents

About this Book
Dedication
Foreword
Introduction
Acknowledgments
About the Author
Section I. Data Interpretation
- Chapter 1. Data Interpretation Overview
  - Purpose of This Book
  - The Interpretation Process
  - Characteristics of Ideal Data
  - Guidance for DNA Interpretation
  - A Match or not a Match: That is the Question…
  - STR Loci, Kits, and Population Data
  - Summary
- Chapter 2. Data, Models, Thresholds
  - Data Collection in ABI Genetic Analyzers
  - Models
  - Thresholds Used in STR Typing
  - Setting and Using Analytical Thresholds
- Chapter 3. STR Alleles and Amplification Artifacts
  - Introduction
  - Overview of the STR Typing Process
  - STR Alleles and Their Measurement
  - Variant and “Off-Ladder” Alleles
  - Artifacts of STR Allele Amplification
  - Non-Template Addition
  - Stutter Products
  - Null (Silent) Alleles
- Chapter 4. STR Genotypes: Heterozygote Balance, Stochastic Thresholds, Allele, and Concordance Studies
  - Importance of Genotypes vs. Alleles
  - Peak Height Ratios
  - Stochastic Thresholds and Allele Drop-out
  - Concordance Studies and Null Alleles
- Chapter 5. STR Profiles: Multiplex PCR, Tri-Alleles, Amelogenin, and Partial Profiles
  - Introduction
  - Multiplex PCR Challenges
  - STR Profile Evaluation
  - Tri-Allelic Patterns
  - Gender Identification with Amelogenin
  - Partial DNA Profiles
- Chapter 6. DNA Mixtures
  - General Information
  - Tools for Mixture Interpretation
  - Elements of Mixture Interpretation
  - Resources and Guidance on Mixture Interpretation
  - Complicating Factors in Mixture Deconvolution
- Chapter 7. Low-Level DNA and Complex Mixtures
  - Interpretation Challenges with Low Template DNA
  - Low-Quantity and Low-Quality DNA
  - Probabilistic Genotyping
  - High-Density SNP Arrays?
  - More Poor-Quality Samples Being Submitted
  - A Complexity Threshold?
- Chapter 8. Troubleshooting Data Collection
  - Introduction
  - Principles and Processes Involved with Capillary Electrophoresis
  - Instrument Maintenance & Common Problems
  - Recommended Steps for Troubleshooting
  - Summary
Section II. Statistical Interpretation
- Chapter 9. Statistical Interpretation Overview
  - Role of Statistics in Forensic DNA
  - Probability
  - Statistics
- Chapter 10. STR Population Data Analysis
  - Introductory Genetic Principles
  - Population Data
  - Genetic Models and Formulas
  - Practical Considerations
  - Summary
- Chapter 11. DNA Profile Frequency Estimates and Match Probabilities
  - Introduction
  - Profile Frequency Estimate Calculations
  - Likelihood Ratio
  - Source Attribution
  - Issues with DNA Profile Frequency Estimates
  - Summary
- Chapter 12. DNA Mixture Statistics
  - Introduction
  - Different Statistical Approaches to Mixture Interpretation
  - Reporting Match Probabilities on Deduced Components
  - Random Man not Excluded (RMNE)
  - Likelihood Ratios
  - Additional Topics
- Chapter 13. Coping with Potential Missing Alleles
  - Introduction to the Problem
  - Probabilistic Genotyping – A Way Forward
- Chapter 14. Relationship Testing: Kinship Statistics
  - Introduction
  - Parentage Testing
  - Mutations and Mutation Rates
  - Other Topics with Parentage Testing
  - Missing Persons & Disaster Victim Identification
  - Complex Kinship Analysis
- Chapter 15. Lineage Marker Statistics
  - Lineage Marker Inheritance Patterns
  - Guidance on Interpretation
  - Generating Lineage Marker Haplotypes
  - Population Databases for Lineage Markers
  - Genetic Models and Reporting
  - Summary Thoughts
- Chapter 16. Laboratory Reports: Communicating Results and Conclusions
  - Introduction
  - Drawing Conclusions
  - Report Writing
  - Report & Case Review
  - Report Release
  - Report Comprehension and Potential Misuse
  - Summary
Appendix 1. STR Allele Frequencies from U.S. Population Data
Appendix 2. NRC I & NRC II Recommendations
Appendix 3. DAB Recommendations on Statistics
Appendix 4. Worked Mixture Example
Index

Book details

ISBN: 9780124052130

Page Count: 608

Retail Price : £78.99

Advanced Topics in Forensic DNA Typing: Methodology, Butler, 9780123745132, $99.95, 680 pp., Elsevier, 7/2011
Forensic Pathology: Principles and Practice, Matshes, et al, 9780122199516, $290.00, 690 pp., Elsevier, 4/2005
Forensic Neuropathology, Itabashi, 9780120585274, $235.00, 496 pp., Academic Press, 8/2007

Audience

Researchers and practitioners in forensic DNA analysis, forensic scientists; legal professionals, military, private and public forensic laboratories, forensic science graduate and post-graduate students.

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