Handbook of Synthetic Organic Chemistry - Edition 2 - By Michael C. Pirrung Elsevier Inspection Copies

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Handbook of Synthetic Organic Chemistry,

Edition 2

By Michael C. Pirrung

Publication Date: 15 Sep 2016

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Description

Handbook of Synthetic Organic Chemistry, Second Edition updates and expands the author’s popular 2007 work, Synthetic Organic Chemist’s Companion. This new handbook provides valuable, practical guidance; incorporates corrections, and includes coverage on important topics, such as lyophylization, crystallization, precipitation, HPLC detectors, gases, and microwave reactions.

The book maintains the useful organization of the author’s earlier work, beginning with a basic overview and walking through every practical step of the process of organic synthesis, from reagents, solvents, and temperature control, to documentation, implementation, purification, and analytical methods for the product.

From planning and setting up reactions, to recording them, the book provides insight and valuable guidance into every step of the process.

Key Features

Contains practical information for every part of the process that are coupled with engaging, real-world examples
Presents useful guidance for conducting literature searches, handling and preparing reagents, working up the reaction, and identifying the product
Presents valuable coverage of conventional and microwave temperature control, paper and electronic research notebooks, eluent selection, Schlenk lines, purification methods and determination, chiral chromatography, chemical safety, and more

About the author

By Michael C. Pirrung, University of California, Riverside, USA

Table of Contents

Foreword
Preface to the First Edition
Preface to the Second Edition
Acknowledgments
1. Safety
- 1.1. Training
- 1.2. Safety Data Sheets
- 1.3. Safety Pictograms
- 1.4. Personal Protective Equipment
- 1.5. General
2. Searching the Literature
- 2.1. Commercial Availability
- 2.2. Literature Preparations
- 2.3. Experimental Procedures
- 2.4. Other Electronic Resources for Synthetic Chemistry
3. Reagents
- 3.1. Short-Path Distillation
- 3.2. Ampules
- 3.3. Reagent Solutions
- 3.4. Titration
- 3.5. Reagent Storage
- 3.6. Subtle Reagent Variations
- 3.7. Dangerous Reagents
- 3.8. Reagent Properties
4. Gases
- 4.1. Lecture Bottles/Small Cylinders
- 4.2. Tanks or Cylinders
- 4.3. Gas Safety
5. Reactions on a Small Scale—1–25mmol
- 5.1. Reaction Flasks
- 5.2. Stirring
- 5.3. Glass Joints
- 5.4. Inert Atmosphere
- 5.5. Apparatus for Addition
- 5.6. Condensers
- 5.7. Other Equipment and Considerations
6. Temperature Control
- 6.1. Heating
- 6.2. Cooling
7. Solvents
- 7.1. Selection
- 7.2. Purity
- 7.3. Degassing
- 7.4. Ammonia
8. The Research Notebook
- 8.1. Paper Notebooks
- 8.2. Electronic Notebooks
9. Conducting the Reaction Itself
- 9.1. Reagents Supplied as Dispersions
- 9.2. Azeotropic Drying
- 9.3. Stoichiometry
- 9.4. Syringe and Inert Atmosphere Techniques
- 9.5. General Procedure for Transfer of Materials by Syringe
- 9.6. Addition
- 9.7. Special Techniques
- 9.8. Unattended Reactions
- 9.9. Quenching
- 9.10. Specialized Reagents
- 9.11. Checklist
- 9.12. Reaction Time Versus Purification Time
10. Following the Reaction
- 10.1. Thin Layer Chromatography
- 10.2. Gas Chromatography
- 10.3. High Performance Liquid Chromatography
- 10.4. Nuclear Magnetic Resonance Spectroscopy
11. Working Up Reactions
- 11.1. Solvent Extraction
- 11.2. Drying Organic Solutions
- 11.3. Specialized Workups
- 11.4. Destroying Reagents
12. Evaporation
13. Vacuum Systems
- 13.1. Vacuum Sources
- 13.2. Vacuum Manifolds
- 13.3. Vacuum Gauges
14. Purification of Products
- 14.1. Distillation
- 14.2. Silica Gel Chromatography
- 14.3. Flash Column Chromatography
- 14.4. Gradients
- 14.5. Special Adsorbents
- 14.6. Preparative Gas Chromatography
- 14.7. Precipitation
- 14.8. Trituration
- 14.9. Crystallization
- 14.10. Yields
15. Methods for Structure Elucidation
- 15.1. Nuclear Magnetic Resonance Spectroscopy
- 15.2. Infrared Spectroscopy
- 15.3. Ultraviolet Spectroscopy
- 15.4. Combustion Analysis
- 15.5. Mass Spectrometry
- 15.6. Optical Rotation
- 15.7. Chiral Chromatography
- 15.8. Crystal Growth for X-Ray
- 15.9. Novel Compound Characterization
16. Cleaning Up After the Reaction
- 16.1. Waste Disposal
- 16.2. Cleaning Equipment
17. Specific Example
- 17.1. The Experimental
- 17.2. The Org. Syn. Prep
- 17.3. Comparison
18. Strategies for Reaction Optimization
Appendix 1. Safety Protocols
Appendix 2. Synthetic Solvent Selection Chart
Appendix 3. Solvent Miscibility
Appendix 4. Freezing Points of Common Organic Solvents
Appendix 5. Toxicities of Common Organic Solvents
Appendix 6. Recipes for TLC Stains
Appendix 7. NMR Spectral Data of Common Contaminants of Organic and Organometallic Reaction Products
Appendix 8. Acidities of Organic Functional Groups
Appendix 9. Acidities of Organic Functional Groups in DMSO
Appendix 10. Stuck Joints
Index

Book details

ISBN: 9780128095812

Page Count: 288

Retail Price : £73.99

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Student Resources

Companion Site

Audience

Organic chemistry researchers and advanced students

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