The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common.
This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field.
Key Features
- Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features
- Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration
- Details features, advantages and limitations of animal models, as well as prospects for therapeutic development
- Authored by internationally recognized leaders in the field
- Includes illustrations that help clarify and consolidate complex concepts
1. General Overview
Michael S. Wolfe
2. Prion Diseases
Robert C.C. Mercer, Alex J. McDonald, Erin Bove-Fenderson, Cheng Fang, Bei Wu and David Harris
3. Alzheimer’s disease: towards a quantitative biological approach in describing its natural history and underlying mechanisms
Colin Masters
4. Neurodegeneration and the ordered assembly of Tau
Michael Goedert
5. ALS and Other TDP43 Proteinopathies
Christopher Shaw and Jorge Gomez-Deza
6. Parkinson’s Disease and Other Synucleinopathies
Mark R. Cookson
7. Huntington’s Disease and Other Polyglutamine Disorders
Albert R. La Spada and Audrey Dickey
8. Prion-like propagation in Neurodegenerative Diseases
Patrik Brundin, Veerle Baekelandt and Wouter Peelaerts
9. Neurodegenerative Diseases as Protein Folding Disorders
Jack Mathew Webster
10. Heat shock proteins and protein quality control in Alzheimer's disease
Fred van Leeuwen and Harm H. Kampinga
11. Neurodegenerative Diseases and Autophagy
David C. Rubinsztein
12. Neurodegenerative Diseases and Axonal Transport
Larry Goldstein and Utpal Das
13. Mitochondrial Function and Neurodegenerative Diseases
Russell Swerdlow
14. Neurodegenerative Diseases and Non-cell autonomous toxicity
Azad Bonni
15. Neurodegenerative Diseases and RNA-mediated toxicity
Tiffany Todd and Leonard Petrucelli
16. Neuroinflammation in Age-Related Neurodegenerative Diseases
Kathryn MacPherson, Maria Elizabeth de Sousa Rodrigues, Amarallys F. Cintron and Malú G. Tansey
17. Neurodegenerative Diseases and the Aging Brain
Stephen Kenneth Godin, Jinsoo Seo, and Li-Huei Tsai
- Fantini and Yahi, Brain Lipids in Synaptic Function and Neurological Disease, Jul 2015, 9780128001110, $125.00
- Coleman and Tsongalis, Molecular Pathology: The Molecular Basis of Human Disease 2e, Feb 2017, 9780128027615, $120.00
- Verstreken, Parkinson’s Disease: Molecular Mechanisms Underlying Pathology, Jul 2017, 9780128037836, $99.95
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