Toxicoepigenetics: Core Principles and Applications examines the core aspects of epigenetics, including chromatin biology, DNA methylation, and non-coding RNA, as well as fundamental techniques and considerations for studying each of these mechanisms of epigenetic regulation. Although its integration into the field of toxicology is in its infancy, epigenetics have taken center stage in the study of diseases such as cancer, diabetes, and neurodegeneration. Increasing the presence of epigenetics in toxicological research allows for a more in-depth understanding of important aspects of toxicology such as the role of the environment and lifestyle influencing the individual susceptibility to these effects and the trans-generational transmission of these health effects and susceptibilities. Methods chapters are included to help improve efficacy and efficiency of protocols in both the laboratory and the classroom. Toxicoepigenetics: Core Principles and Applications is an essential book for researchers and academics using epigenetics in toxicology research and study.
Key Features
- Introduces the fundamental principles and practices for understanding the role of the epigenome in toxicology
- Presents the foundation of epigenetics for toxicologists with a broad range of backgrounds
- Discusses the incorporation of epigenetics and epigenomics into current toxicological studies and interpretation of epigenetic data in toxicological applications
Prelude
Introduction to the Role of the Epigenome in Health and Disease
Section 1
1. The Role of Histone Acetylation and Acetyltransferases in Gene Regulation
2. The Role of Histone Methylation and Methyltransferases in Gene Regulation
3. Linking Chromatin Accessibility with Exposure Effects and Susceptibility
4. Implications for Chromatin Biology in Toxicology
Section 2
5. The Role of DNA Methylation in Gene Regulation
6. Implications of DNA Methylation in Toxicology
7. DNA Methylation as a Biomarker in Environmental Epidemiology
8. DNA Hydroxymethylation: Implications for Toxicology and Epigenetic Epidemiology
Section 3
9. The Role of Non-Coding RNAs in Gene Regulation
10. miRNAs and lncRNAs as Biomarkers of Toxicant Exposure
Section 4
11. Germline and Trans-generational Impacts of Toxicant Exposures
12. Novel Bioinformatics Methods for Toxicoepigenetics
13. Incorporating Epigenetics into Risk Assessment Frameworks
Section 5
14. Chromatin Immunoprecipitation: General Protocol and Considerations for Analysis
15. Methods for Analysis of DNA Methylation
16. Methods for Analyzing miRNA Expression
- Miller, The Exposome: A Primer, Dec 2013, 9780124172173, $39.95
- Gupta, Biomarkers in Toxicology, Feb 2014, 9780124046306, $250.00
- Kleinjans, Toxicogenomics-Based Cellular Models, Jan 2014, 9780123978622, $129.95
Researchers, academics, and advanced students and in toxicology and related fields. Investigators, risk assessors and regulators in academia, industry and government.
