Neurobiology of Depression,
Edition 1 Road to Novel Therapeutics
Edited by Joao Quevedo, Andre Ferrer Carvalho, M.D., Ph.D. and Carlos A. Zarate

Publication Date: 08 Jan 2019

Neurobiology of Depression: Road to Novel Therapeutics synthesizes the basic neurobiology of major depressive disorder with discussions on the most recent advances in research, including the interacting pathways implicated in the pathophysiology of MDD, omics technologies, genetic approaches, and the development of novel optogenetic approaches that are changing research perspectives and revolutionizing research into depression. These basic foundational understandings on the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research are combined in this book to aid advanced students and researchers in their understanding of MDD.

Depression is one of the most common mental-health disorders caused by a variety of genetic, biological, environmental and psychological factors. Major depressive disorder (MDD) is typically treated with first-line antidepressant agents that primarily target monoamine neurotransmission. However, only approximately one-third of patients with MDD achieve remission following a trial with such an antidepressant. Furthermore, MDD is a heterogeneous phenotype, and new frameworks, such as the NIMH Research Domain Criteria (RDoC) may provide a more accurate, biologically based comprehension of the symptomatic heterogeneity of this devastating illness.

Key Features

  • Aids readers in understanding major depressive disorder in the context of NIMH Research Domain Criteria (RDoC) recommendations
  • Covers a range of existing and potential pharmacologic and non-pharmacologic treatment options, from lifestyle adjustments, to antidepressants and novel therapeutics
  • Synthesizes discussions on the cellular and molecular mechanisms underlying symptoms with the clinical aspects of depression
About the author
Edited by Joao Quevedo, Professor of Psychiatry at the McGovern Medical School, The University of Texas Health Science Center at Houston, TX, USA; Andre Ferrer Carvalho, M.D., Ph.D., Associate Professor, Department of Psychiatry, Temerty Medical School, University of Toronto, Toronto, ON, Canada and Carlos A. Zarate, Chief, Experimental and Therapeutics Branch/Section on Neurobiology and Treatment of Mood and Anxiety Disorders, and Clinical Professor of Psychiatry and Behavioral Sciences, George Washington University, USA
Book details
ISBN: 9780128133330
Page Count: 471
Retail Price : £118.00
  • Zigmond, Neurobiology of Brain Disorders, Dec 2014, 9780123982704, $150.00
  • Frodl, Systems Neuroscience in Depression, Mar 2016, 9780128024560, $150.00
  • Schlaepfer, Neurobiology of Psychiatric Disorders (Handbook of Clinical Neurology vol. 106), Jul 2012, 9780444520029, $275.00
Advanced students and researchers in neuroscience, psychology, medicine, health sciences, and pharmacology
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