Rosenberg’s Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Sixth Edition: Volume Two provides a comprehensive introduction and reference to the foundations and practical aspects relevant to the majority of neurologic and psychiatric disease. This updated volume focuses on degenerative disorders, movement disorders, neuro-oncology, neurocutaneous disorders, epilepsy, white matter diseases, neuropathies and neuronopathies, muscle and neuromuscular junction disorders, stroke, psychiatric disease, and a neurologic gene map. A favorite of over three generations of students, clinicians and scholars, this new edition retains and expands on the informative, concise and critical tone of the first edition.
This is an essential reference for general medical practitioners, neurologists, psychiatrists, geneticists, related professionals, and for the neuroscience and neurology research community at large. The content covers all aspects essential to the practice of neurogenetics to inform clinical diagnosis, treatment and genetic counseling.
Key Features
- Provides comprehensive coverage on the neurogenetic foundation of neurological and psychiatric disease
- Presents detailed coverage of genomics, animal models and diagnostic methods, with new coverage on evaluating patients with biochemical abnormalities or gene mutations
- Includes new chapters on the pharmacogenomics of epilepsy and the most recent updates in molecular genetics, focusing on neurodegenerative and psychiatric diseases
1. Genomics of Alzheimer’s disease
2. Parkinson disease and related disorders
3. Frontotemporal dementia
4. The neuronal ceroid-lipofuscinoses (Batten disease)
SECTION II. MOVEMENT DISORDERS
5. The inherited ataxias
6. Friedreich ataxia
7. Ataxia-telangiectasia
8. Dystonia
9. Huntington’s disease: clinical features, disease mechanisms, and management
10. The hereditary spastic paraplegias
SECTION III. NEURO-ONCOLOGY
11. Glioblastoma
SECTION IV. NEUROCUTANEOUS DISORDERS
12. Neurofibromatosis type 1
13. Tuberous sclerosis complex
14. Sturge-Weber syndrome
15. Hemangioblastomas of the central nervous system
16. Incontinentia pigmenti
SECTION V. EPILEPSY
17. Epilepsy genetics—considerations for clinical practice today and for the future
SECTION VI. WHITE MATTER DISEASES
18. Multiple sclerosis
19. Vanishing white matter disease
SECTION VII. NEUROPATHIES AND NEURONOPATHIES
20. Amyotrophic lateral sclerosis
21. Peripheral neuropathies
22. Spinal muscular atrophy
23. Pain genetics
SECTION VIII. MUSCLE AND NEUROMUSCULAR JUNCTION DISORDERS
24. Dystrophinopathies
25. Limb-girdle muscular dystrophy
26. The congenital myopathies
27. The distal myopathies
28. Hereditary inclusion-body myopathies
29. The myotonic dystrophies
30. Facioscapulohumeral muscular dystrophy
31. Muscle channelopathies: periodic paralyses and nondystrophic myotonias
32. Congenital myasthenic syndromes
SECTION IX. STROKE
33. Cerebral vasculopathies
34. Coagulopathies
35. Sickle cell disease
Sub-Section: Psychiatric Disease
36. Unipolar depression
37. Bipolar disorder
38. Schizophrenia
39. Obsessive
41. Addiction
SECTION X. A NEUROLOGIC GENE MAP
42. A neurologic gene map
9780124051959; 9780123982704; 9780123865250; 9780128030585
Clinical neurologists, psychiatrists, psychologists, neuroscience researchers, clinical neurology researchers, general medical practitioners, and genetic and molecular biologists with an interest in neurogenetics
