Diagnosis and Management in Dementia,
Edition 1 The Neuroscience of Dementia, Volume 1
Edited by Colin R Martin and Victor R Preedy, BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC

Publication Date: 18 Sep 2020
Diagnosis and Management in Dementia: The Neuroscience of Dementia, Volume 1 consolidates different fields of dementia into a single book, covering a range of subjects, including Alzheimer’s disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, molecular biology, and more. With an impact on millions globally, and billions of research dollars being invested in dementia research, this book will stimulate research in the area and inform researchers.

Key Features

  • Offers comprehensive coverage of a broad range of topics related to dementia
  • Serves as a foundational collection for neuroscientists and neurologists on the biology of dementia and brain dysfunction
  • Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding
  • Provides unique sections on specific subareas, intellectual components, and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendations
  • Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations
  • Serves as a "one-stop" source for everything you need to know about dementia
About the author
Edited by Colin R Martin, Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director: Institute for Health and WellbeingUniversity of Suffolk, Ipswich, UK and Victor R Preedy, BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC, Professor in the Department of Clinical Biochemistry at King’s College Hospital, London, UK Emeritus Professor in Faculty of Life Sciences and Medicine at King’s College London, UK Visiting Professor at the University of Hull, UK
Table of Contents

Part I: Dementia: introductory chapters and setting the scene

1. Mixed dementia: a neuropathological overviewJacques De Reuck

2. Vascular dementia: an overviewVirginia Cipollini, Fernanda Troili and Franco Giubilei

3. Small vessel disease and dementiaFrancesco Arba and Valentina Rinnoci

4. Linking amyotrophic lateral sclerosis and frontotemporal dementiaCouratier Philippe

5. Mortality in dementia: linking in the role of deliriumFlavia Barreto Garcez and Thiago Junqueira Avelino-Silva

6. Midlife diabetes and the risk of dementia: understanding the linkAdam H. Dyer and Sean P. Kennelly

7. Gait and dementiaOshadi Jayakody and Michele L. Callisaya

8. The role of blood pressure and hypertension in dementiaKeenan A. Walker and Rebecca F. Gottesman

9. Genetics of dementia: a focus on Alzheimer’s diseaseFrancesca Fernandez and Jessica L. Andrews

10. Clinical and pathological phenotypes in dementia: a focus on autosomal dominant frontotemporal dementiaInnocenzo Rainero, Alessandro Vacca and Elisa Rubino

11. Environmental and genetic risk factors for dementiaVanesa Bellou, Lazaros Belbasis and Evangelos Evangelou

12. Lipids, brain ageing, dementia, and lipidomicsAnne Poljak, Braidy Nady, Wong Matthew Wai Kin, Yue Liu, Mahboobeh Housseini and Sachdev Perminder Singh

13. The 5xFAD mouse model of Alzheimer’s disease Caroline Ismeurt, Patrizia Giannoni and Sylvie Claeysen

Part II: Biomarkers, psychometric instruments and diagnosis

14. Use of cerebrospinal fluid in diagnosis of dementiaAngelo Nuti, Cecilia Carlesi, Elena Caldarazzo Ienco, Gabriele Cipriani and Paolo Del Dotto

15. Salivary biomarkers in Alzheimer’s disease Jessica L. Andrews and Francesca Fernandez

16. Diacylglycerols: biomarkers of a sustained immune response in proteinopathiesPaul L. Wood and Randall J. Woltjer

17. Butyrylcholinesterase as a biomarker in Alzheimer’s diseaseDrew R. DeBay and Sultan Darvesh

18. Blood brain-derived neurotrophic factor as a biomarker of Alzheimer’s diseaseMarta Balietti

19. The neuroscience of dementia: diagnosis and management methods of amyloid positron emission tomography imaging and its application to the Alzheimer’s disease spectrumShizuo Hatashita

20. Diffusion-weighted imaging (DWI) tractography and Alzheimer’s diseaseNicola Amoroso

21. Transcranial magnetic stimulation in the cortical exploration of dementiaThanuja Dharmadasa, William Huynh and Matthew C. Kiernan

22. The role of retinal imaging in Alzheimer’s diseaseVictor T.T. Chan and Carol Y. Cheung

23. Prediction of Alzheimer’s diseaseAthanasios Alexiou, Stylianos Chatzichronis and Ghulam Md Ashraf

24. Addenbrooke’s Cognitive ExaminationJordi A. Matias-Guiu

25. Beyond the cutoffs: a Bayesian approach to the use of the Montreal Cognitive Assessment as a screening tool for mild cognitive impairment and dementiaAndrea Bosco, Alessandro O. Caffo, Giuseppina Spano and Antonella Lopez

26. Utility of ALBA screening instrument: the prodromal phase of dementia with Lewy bodiesWaleska Berríos and Angel Golimstok

27. The quick mild cognitive impairment screen and applications to dementia Ron an O’Caoimh, D. William Molloy and Roger Clarnette

28. The usefulness of evaluating performance of activities of daily living in the diagnosis of mild cognitive disordersPatricia De Vriendt, Elise Cornelis and Ellen Gorus

Part III: Pharmacological treatments for dementia

29. Cholinesterase inhibitors in dementias: an overviewPatrizia Mecocci, Lucia Paolacci and Virginia Boccardi

30. Choline-containing phospholipids and treatment of adult-onset dementia disordersFrancesco Amenta, Gopi Battineni, Enea Traini and Graziano Pallotta

31. Donepezil in the treatment of Alzheimer’s diseaseGabriella Marucci, Michele Moruzzi and Francesco Amenta

32. Memantine and Alzheimer’s disease: a comprehensive reviewSergio del Río-Sancho

33. A new neuroprotective strategy for the drug therapy of Parkinson’s disease: the Ca2þ/cAMP signaling as therapeutic targetAfonso Caricati-Neto, Fulvio Alexandre Scorza and Leandro Bueno Bergantin

34. Pitfalls and possible solutions for research and development of dementia therapiesThomas Muller €

35. All-trans retinoic acid in Alzheimer’s diseaseSiamak Beheshti

36. Dementia and usage of N-methyl-D-aspartate receptor antagonistsB.E. Glynn-Servedio

37. Swallowing impairment in Parkinson’s diseaseMaira Rozenfeld Olchik, Marina Padovani and Annelise Ayres

38. Linking astrocytes’ exosomes to Alzheimer pathogenesis and therapyAnna M. Chiarini, Ubaldo Armato, Claudio Eccher and Ilaria Dal Pr

39. Changing fate: therapeutic mechanisms focused on the switch of amyloid precursor protein processingSven Reinhardt and Kristina Endres

40. Acetylcholinesterase inhibitory agents in plants and their application to dementia: Alzheimer’s diseaseWillian Orlando Castillo-Ordonez and Nohelia Cajas-Salazar

41. Removal of blood amyloid-b as an effective and safe therapeutic strategyNobuya Kitaguchi, Kazunori Kawaguchi and Kazuyoshi Sakai

Part IV: Non-pharmacological treatments and procedures

42. Caring for people with dementia in the acute hospitalRobert Briggs, Paul Claffey and Sean P. Kennelly

43. Environmental enrichment as a preventative and therapeutic approach to Alzheimer’s diseaseKimberley E. Stuart, Anna E. King and James C. Vickers

44. Music therapy in dementia: the effects of music therapy and other musical interventions on behavior, emotion, and cognitionAlfredo Raglio and Lapo Attardo

45. Exploitation of aromatherapy in dementiadimpact on pain and neuropsychiatric symptomsDamiana Scuteri, Laura Rombol

46. Dancing in dementiaLee-Fay Low, Helen Parker, Kathryn Dovey and Alycia Fong Yan

47. Hypoxicehyperoxic conditioning and dementiaRobert T. Mallet, Johannes Burtscher, Eugenia B. Manukhina, H. Fred Downey, Oleg S. Glazachev, Tatiana V. Serebrovskaya and Martin Burtscher

48. Linking amyloid and depression in the development of Alzheimer’s disease: effects of neuromodulatory interventions by brain stimulationAkihiko Nunomura, Toshio Tamaoki, Kenji Tagai, Shinsuke Kito, Shunichiro Shinagawa and Masahiro Shigeta

49. Regional and local dementia care networksFranziska Laporte Uribe, Karin Wolf-Ostermann, Jochen Rene Thyrian and Bernhard Holle

50. Cognitive behavioral therapy use in Alzheimer’s disease: mitigating risks associated with the olfactory brainLarry D. Reid, Dylan Z. Taylor and Alicia A. Walf

51. Maximizing cognition in mild cognitive impairment and early stage dementiaBridget Regan, Yvonne Wells and Paul O’Halloran

52. Exercise, cognitive creativity, and dementiaEmily Frith and Paul D. Loprinzi

53. Person-centered communication among formal caregivers of persons with dementiaMarie Y. Savundranayagam and Pabiththa Kamalraj


Book details
ISBN: 9780128158548
Page Count: 910
Retail Price : £157.00
Zigmond, Coyle and Rowland, Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders 1e, December 2014, 9780123982704, $150.00Forthcoming:Coleman and Tsongalis, Molecular Pathology: The Molecular Basis of Human Disease 2e, October 2017, 9780128027615, $150.00Lewis and Spillane, The Molecular Pathology of Neurodegenerative Disease, March 2018, 9780128110690, $99.95Wolfe, The Molecular and Cellular Basis of Neurodegenerative Diseases, March 2018, 9780128113042, $99.95
Neuroscientists/neurologists, psychologists, health scientists, public health workers, research scientists, pharmacologists, and physicians. It is suitable for graduate/postgraduate students, lecturers, and professors.