Genetics, Neurology, Behavior, and Diet in Dementia,
Edition 1 The Neuroscience of Dementia, Volume 2
Edited by Colin R Martin and Victor R Preedy, BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC

Publication Date: 21 Sep 2020
Genetics, Neurology, Behavior, and Diet in Dementia: The Neuroscience of Dementia, Volume 2 consolidates different fields of dementia research into a single book, covering a range of subjects, including Alzheimer’s disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, and molecular biology. This foundational, comprehensive book assembles the latest understanding on all dementias and their common features in a single source. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field.

Key Features

  • Offers comprehensive coverage of a broad range of topics related to dementia
  • Serves as a foundational collection for neuroscientists and neurologists on the biology of dementia and brain dysfunction
  • Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding
  • Provides unique sections on specific subareas, intellectual components, and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendations
  • Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations
  • Serves as a "one-stop" source for everything you need to know about dementia
About the author
Edited by Colin R Martin, Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director: Institute for Health and WellbeingUniversity of Suffolk, Ipswich, UK and Victor R Preedy, BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC, Professor in the Department of Clinical Biochemistry at King’s College Hospital, London, UK Emeritus Professor in Faculty of Life Sciences and Medicine at King’s College London, UK Visiting Professor at the University of Hull, UK
Table of Contents

Part I: Genetics, molecular and cellular biology

1. The neuron navigator 2 gene and Alzheimer’s diseaseChun Xu, Brenda Bin Su, Stephanie Lozano and Kesheng Wang

2. Interlinking polymorphisms, estrogens, and Alzheimer diseaseLu Hua Chen, Leung Wing Chu and You-Qiang Song

3. Linking EEGs, Alzheimer disease, and the phosphatidylinositol-binding clathrin assembly protein (PICALM) geneNatalya Ponomareva, Tatiana Andreeva, Vitaly Fokin, Sergey Illarioshkin and Evgeny Rogaev

4. CD36 gene polymorphisms and Alzheimer’s diseaseOmar Šerý, Nandu Goswami and Vladimir J. Balcar

5. Genetic contributions to sporadic frontotemporal dementiaJessie S. Carr, Daniel W. Sirkis and Jennifer S. Yokoyama

6. Clinical response to cholinesterase inhibitors in dementia: the role of CYP2D6 and APOE genetic polymorphismsLuís Felipe José Ravic de Miranda, Karina Braga Gomes and Paulo Caramelli

7. A1 and A2 purinergic receptor expression in dementiaJ. Mendiola-Precoma, L.C. Berumen, A. Rodríguez-Cruz and G. García-Alcocer

8. Molecular aspects of metallothioneins in dementiasGemma Comes, Anna Escrig, Yasmina Manso, Olaya Fernández-Gayol, Paula Sanchis, Amalia Molinero, Mercedes Giralt, Javier Carrasco and Juan Hidalgo

9. Implication of microRNAs in Alzheimer’s disease pathogenesisKatarzyn Marta Zoltowska, Katarzyna Laskowska-Kaszub, Siranjeevi Nagaraj and Urszula Wojda

10. Role of cellular oxidative stress in dementiaGiovanna Galliciotti, Antonella De Jaco, Diego Sepulveda-Falla, Emanuela D’Acunto and Elena Miranda

11. Toward an integrative understanding of the neuroinflammatory molecular milieu in Alzheimer disease neurodegenerationJuan M. Zolezzi, Paulina Villaseca and Nibaldo C. Inestrosa

12. Wnt signaling and dementiaCarolina Alquezár and Ángeles Martín-Requero

13. Linkage of atypical protein kinase C to Alzheimer diseaseRobert V. Farese and Mini P. Sajan

14. Linking histone deacetylases and phosphodiesterase 5 in novel treatments for Alzheimer’s diseaseAna Garcia-Osta and Mar Cuadrado-Tejedor

15. Nuclear factor erythroid 2-related factor 2 in Alzheimer’s diseaseKelsey E. Murphy and Joshua J. Park

16. Implications of alpha- and beta-secretase expression and function in Alzheimer’s diseaseSven Reinhardt and Kristina Endres

17. Methylation analysis of DNA in Alzheimer’s diseaseFabio Coppedè

18. The signalosome malfunctions in age-associated neuropathologiesRicardo Puertas-Avendaño, David Quinto-Alemany, Miriam González-Gómez and Raquel Marin

19. FAM3C in Alzheimer’s disease: a risk-related molecule and potential therapeutic targetMasaki Nishimura, Naoki Watanabe, Emi Hibino, Masaki Nakano, Yachiyo Mitsuishi, Lei Liu and Takuma Sugi

20. Amylin and amylin receptors in Alzheimer’s diseaseWen Fu and Jack H. Jhamandas

21. Mammalian target of rapamycin complexes: regulation and Alzheimer’s diseaseHenry Querfurth and Han-Kyu Lee

22. Mammalian target of rapamycin complexes: protein synthesis and autophagy, Parkinson’s disease, amyotrophic lateral sclerosis, and frontotemporal dementiaHenry Querfurth and Han-Kyu Lee

23. Linking CD200 in brains and dementia: molecular aspects of neuroinflammationDouglas Gordon Walker

Part II: Neurological, physiological and imaging

24. Hippocampal atrophy associated with dementia risk factors and dementiaHiroshi Yao, Yuko Araki, Fumio Yamashita, Makoto Sasaki and Manabu Hashimoto

25. Inflammation and insulin resistance in Alzheimer’s disease: partners in crimeYuval Nash and Dan Frenke

26. Brain susceptibility to hypoxia/hypoxemia and metabolic dysfunction in Alzheimer’s disease: insights from animal and in vitro modelsVito Antonio Baldassarro, Andrea Bighinati, Michele Sannia, Luciana Giardino and Laura Calzà

27. Neuropeptides and neurolipids: what they are and how they relate to Alzheimer’s diseaseIván Manuel, Laura Lombardero, Alberto Llorente-Ovejero and Rafael Rodríguez-Puertas

28. Neurotransmitter receptors in Alzheimer’s disease: from glutamatergic to cholinergic receptorsLaura Lombardero, Alberto Llorente-Ovejero, Iván Manuel and Rafael Rodríguez-Puertas

29. Aß42-a7-like nicotinic acetylcholine receptors and Alzheimer’s diseaseHoau-Yan Wang and Amber Khan

30. Synaptosomal bioenergetic defects in Alzheimer’s diseasePamela V. Martino Adami and Laura Morelli

31. Limitations of amyloid imaging in Alzheimer’s diseaseDavid Weidman

32. Linking gradient echo plural contrast imaging metrics of tissue microstructure with Alzheimer diseaseDmitriy A. Yablonskiy, Tammie L. Benzinger and John C. Morris

33. Hypertensive disorders during pregnancy and later dementia: is there a connection?Ellika Andolf

34. Unraveling the contributions of sleep dysfunction to Alzheimer’s diseaseElie Gottlieb, Natalie A. Grima, Mark Howard, Amy Brodtmann and Matthew P. Pase

Part III: Behaviour and psychopathology

35. Overview of behaviors in dementiaDorothy M. Grillo and Rachel Anderson

36. Delirium superimposed on dementia: a clinical challenge from diagnosis to treatmentMorandi Alessandro, Pozzi Christian, Grossi Eleonora and Bellelli Giuseppe

37. Self-consciousness deficits in dementiaEva M. Arroyo-Anlló and Roger Gil

38. Attentional impairments to novel images in dementiaCelina S. Liu, Michael Rosen, Nathan Herrmann and Krista L. Lanctôt

39. Frontal lobe syndrome and dementiasPetronilla Battista, Chiara Griseta, Rosa Capozzo, Madia Lozupone, Rodolfo Sardone, Francesco Panza and Giancarlo Logroscino

40. The stigma of dementiaAlbert Aboseif and Benjamin K.P. Woo

41. Delusions in dementiasMadia Lozupone, Maddalena La Montagna, Antonello Bellomo, Petronilla Battista, Davide Seripa, Antonio Daniele, Antonio Greco, Onofrio Resta, Giancarlo Logroscino and Francesco Panza

42. Linking motor speech function and dementiaMatthew L. Poole and Adam P. Vogel

43. Spatial navigation and Alzheimer’s diseaseLaura E. Berkowitz, Ryan E. Harvey and Benjamin J. Clark

44. Violence and dementiaG. Cipriani, S. Danti, A. Nuti, L. Picchi and M. Di Fiorino

45. Factors contributing to protection and vulnerability in dementia caregiversFan Zhang, Sheung-Tak Cheng and Manuel Gonçalves-Pereira

Part IV: Diet, nutrition and environment

46. Nutritional status of dementia and management using dietary taurine supplementationMi Ae Bae and Kyung Ja Chang

47. Selenium and Alzheimer’s diseaseAdriana Gisele Hertzog da Silva Leme and Barbara R. Cardoso

48. Linking adiponectin and obesity in dementiaMa1gorzata Bednarska-Makaruk

49. The impact of the gut microbiome in Alzheimer’s disease: cause or consequence?Malena dos Santos Guilherme and Kristina Endres

50. (-)-Epigallocatechin-3-gallate and Alzheimer’s diseaseLaura Xicota and Rafael de la Torre

51. Lead, cadmium and Alzheimer’s diseaseKelly M. Bakulski, Howard Hu and Sung Kyun Park

Part V: Models and modelling in dementia

52. Alzheimer model 5xfad mice and applications to dementia: transgenic mouse models, a focus on neuroinflammation, microglia, and food-derived componentsTatsuhiro Ayabe and Yasuhisa Ano

53. Use of 192 IgG-saporin as a model of dementia and its applicationJ.W. Chang and Y.S. Park

54. Amyloid beta 1e42-induced animal model of dementia: a reviewJosiane Budni and Jade de Oliveira

55. Resources for the neuroscience of dementiaRajkumar Rajendram and Victor R. Preedy

Book details
ISBN: 9780128158685
Page Count: 952
Retail Price : £157.00
• Zigmond, Coyle and Rowland, Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders 1e, December 2014, 9780123982704, $150.00Forthcoming:• Coleman and Tsongalis, Molecular Pathology: The Molecular Basis of Human Disease 2e, October 2017, 9780128027615, $150.00• Lewis and Spillane, The Molecular Pathology of Neurodegenerative Disease, March 2018, 9780128110690, $99.95• Wolfe, The Molecular and Cellular Basis of Neurodegenerative Diseases, March 2018, 9780128113042, $99.99
Neuroscientists/neurologists, psychologists, health scientists, public health workers, research scientists, pharmacologists, and physicians. It is suitable for graduate/postgraduate students, lecturers, and professors.