Edition 1
By George F. Koob, Michael A. Arends, BS, Mandy L McCracken and Michel Le Moal

Publication Date: 01 Jun 2023

A current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction is detailed in our Neurobiology of Addiction series, each volume addressing a specific area of addiction. Opioids, Volume 4 in the series, explores the molecular, cellular and systems in the brain responsible for opioid addiction using the heuristic three-stage cycle framework of binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation.

Key Features

  • Highlights recent advances in opioid addiction
  • Includes Neurocircuitry, Cellular and Molecular neurobiological mechanisms of opioid addiction
  • Defines opioid abuse and addiction potential, including biological tolerance
About the author
By George F. Koob, Director, National Institute on Alcohol Abuse and Alcoholism and National, Institute on Drug Abuse, National Institutes of Health, Bethesda, MD, USA; Michael A. Arends, BS, Senior Research Assistant, The Scripps Research Institute, La Jolla, CA, USA; Mandy L McCracken, Waggoner Center for Alcohol and Addiction Research, The University of Texas, Austin, TX, USA and Michel Le Moal, Professor Emeritus, University of Bordeaux and Neurocentre Magendie, Inserm, Bordeaux, France
Table of Contents
1. Definitions
2. History of opioid use
3. Mechanism of action: endogenous opioid system
4. Physiological effects
5. Behavioral effects
6. Pharmacokinetics
7. Behavioral mechanism of action
8. Medical use, abuse, and addiction
9. Neurobiological effects
10. Summary
Book details
ISBN: 9780128169889
Page Count: 424
Retail Price : £97.99
9780123736253; 9780123869371; 9780123983367; 9780124186798
Primary: Researchers and graduate students in neuroscience, neurology, psychiatry, and addiction medicine