People use drugs for many different reasons, including the pursuit of "high," social factors and self-medication of other conditions. Many millions of people are addicted to at least one substance, and the cost of addiction is immense, at both the individual and societal levels. Neurocircuitry of Addiction is the first book of its kind, with a focus on addiction neuroscience from a neural circuit perspective. This book begins with a primer on circuit-based neuroscience that equips the reader with an understanding of the applications described throughout the book. Each subsequent chapter positions a different brain region at the "center" of addiction neurocircuitry and goes on to describe the anatomical connectivity of that brain region, how those circuits are affected by drug exposure, and the role of those circuits in controlling addiction-related behaviors. All chapters of this book are written by content experts for a target audience that has some basic neuroscience background, but no prior in-depth knowledge regarding the neurocircuitry of addiction.
Key Features
- Reviews the circuit-based tools that are used by scientists to investigate neural circuit function
- Describes how acute and chronic alcohol and drug exposure affect neural circuit function
- Describes the state of the science regarding the role of specific neural circuis in drug addiction
- Chapters include data from both human neuroscience and animal models
1. Leveraging circuits to understand addiction
Michael C. Salling
2. Midbrain (VTA) circuits
Marisela Morales and M. Flavia Barbano
3. Striatal circuits
Michael S. Patton and Brian N. Mathur
4. Prefrontal Cortical (PFC) circuits
Matthew C. Hearing and John R. Mantsch
5. Insular Cortical circuits
Christine Ibrahim and Bernard Le Foll
6. Thalamic circuits
Alessandra Matzeu, Francisco J. Flores-Ramirez and Rémi Martin-Fardon
7. Hippocampal circuits
Chitra D. Mandyam
8. Amygdala circuits
Lieselot L.G. Carrette, Elizabeth A. Sneddon and Olivier George
9. Bed Nucleus of Stria Terminalis (BNST) circuits
Samuel W. Centanni, Jordan A. Brown, Kellie M. Williford, Elizabeth A. Flook, Joseph R. Luchsinger and Danny G. Winder
10. Noradrenergic circuits
Zoé A. McElligott, Madigan L. Bedard, Sara Y. Conley, Isabel M. Bravo, Elizabeth S. Cogan and Anthony M. Downs
11. Cholinergic modulation of circuits
Nii A. Addy, Christie D. Fowler and Robert J. Wickham
12. Gut-brain axis
Kelly M. Abshire and Lorenzo Leggio
13. Circadian circuits
Mackenzie C. Gamble and Ryan W. Logan
