Neurobiology of Brain Disorders,
Edition 2 Biological Basis of Neurological and Psychiatric Disorders
Edited by Michael J. Zigmond, Clayton A. Wiley and Marie-Françoise Chesselet

Publication Date: 19 May 2022

Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders, Second Edition provides basic scientists a comprehensive overview of neurological and neuropsychiatric disease. This book links basic, translational, and clinical research, covering the genetic, developmental, molecular and cellular mechanisms underlying all major categories of brain disorders. It offers students, postdoctoral fellows, and researchers in diverse fields of neuroscience, neurobiology, neurology, and psychiatry the tools they need to obtain a basic background in the major neurological and psychiatric diseases. Topics include developmental, autoimmune, central, and peripheral neurodegeneration, infectious diseases, and diseases of higher function.

Organized by individual disorder, each chapter includes coverage of the clinical condition, diagnosis, treatment, underlying mechanisms, relevant basic and translational research, and key unanswered questions. This volume reflects progress in the field since publication of the first edition, with fully updated chapters, and new chapters on isolation, aging, global diseases, vascular diseases, and toxic/metabolic disease. New disorder coverage includes fibromyalgia, chronic fatigue, Restless Legs Syndrome, myasthenia gravis, and more.

Key Features

  • Links basic, translational and clinical research on disorders of the nervous system
  • Covers a vast array of neurological and psychiatric disorders, including Down syndrome, autism, muscular dystrophy, diabetes, TBI, Parkinson's, Huntington's, Alzheimer's, OCD, PTSD, schizophrenia, depression and pain
  • Features new chapters on the effects of aging and isolation on brain health
  • Expands coverage on disorders, including new chapters on fibromyalgia, chronic fatigue, and restless legs syndrome
  • Features in-text summary points, special feature boxes and research questions
About the author
Edited by Michael J. Zigmond, Professor, Department of Neurology, University of Pittsburgh, Pennsylvania, USA; Clayton A. Wiley, Clinical Neuropathologist, Pathology Division, University of Pittsburgh Medical Center, PA, USA and Marie-Françoise Chesselet, Emeritus Distinguished Professor, Departments of Neurology and Neurobiology and Emeritus Charles H. Markham Professor of Neurology, David Geffen School of Medicine, UCLA, USA
Table of Contents
Section I: Introductions
1. A Clinical Neuroscientist’s Overview of Disorders of the Brain
Guy McKhann
2: Disease around the world
Vijayalakshmi Ravindranath and Michael Zigmond

Section II. Developmental Disorders
3. Introduction
Aarti Ruparelia and William C. Mobley
4. Developmental Disabilities and Metabolic Disorders
Mary Lee Gregory, Vera Joanna Burton, and Bruce K. Shapiro
5. Attention Deficit/Hyperactivity Disorder
Samuele Cortese and F. Xavier Castellanos
6. Down Syndrome: A Model for Chromosome Abnormalities
Aarti Ruparelia and William C. Mobley
7. Autism Spectrum Disorder
James C. Harris
8. Rett Syndrome: From the Involved Gene(s) to Treatment
Charlotte Kilstrup Nielsen, and Nicoletta Landsberger
9. Fragile X-Associated Disorders
Scott M. Summers and Randi Hagerman

Section III. Diseases of The Peripheral Nervous System
10. Introduction
Henry J. Kaminski
11. Myasthenia Gravis
Linda L. Kusner and Henry J. Kaminski
12. Muscular Dystrophy
Saša A. Živkovic and Paula R. Clemens
13. Peripheral Neuropathies
Mario A. Saporta and Michael E. Shy
14. Diabetes and Cognitive Dysfunction, Catrina Sims-Robinson
Bhumsoo Kim and Eva L. Feldman

Section IV. Diseases of the Central Nervous System and Neurodegeneration
15. Introduction
Elena Cattaneo and Alessandro Vercelli
16. Spinal Cord Injury
Alessandro Vercelli and Marina Boido
17. Vascular Diseases of the Nervous System
Raj Kalaria
18. Toxic/Metabolic Diseases of the Nervous System
Jillian Kril
19. Traumatic Brain Injury
Daniel H. Daneshvar and Ann C. McKee
19. Epilepsy
Helen E. Scharfman
20. Amyotrophic Lateral Sclerosis
O.M. Peters and R.H. Brown
21. Parkinson Disease and Other Synucleinopathies
Thomas Gasser, Thomas Wichmann, and Mahlon R. DeLong
22. Huntington Disease
Matthew P. Parsons and Lynn A. Raymond
23. Alzheimer Disease
Alena V. Savonenko, Tatiana Melnikova, Tong Li, Donald L. Price and Philip C. Wong
24. Cerebrovascular Disease – Stroke
Louis R. Caplan and Roger P. Simon
25. Prion Diseases
Pawel P. Liberski and James W. Ironside

Section V. Infectious and Immune-Mediated Diseases Affecting the Nervous System
26. Introduction
Clayton A. Wiley
27. Role of Inflammation in Neurodegenerative Diseases
Stanley H. Appel, David R. Beers, and Weihua Zhao
28. Role of Inflammation in Psychiatric Disease
Charles L. Raison, Graham W. Rook, Andrew H. Miller and Tommy K. Begay
29. Infections and Nervous System Dysfunction
Krister Kristensson
30. Pathobiology of CNS Human Immunodeficiency Virus Infection
Jennifer L. Lyons, Luis B. Tovar-y-Romo, Kiran T. Thakur, Justin C. McArthur, and Norman J. Haughey
31. Emergent Viral infections of the Nervous System
Clayton A. Wiley
32. Autoimmune and Paraneoplastic Neurological Disorders
Raffaele Iorio, Orna O’Toole, and Sean J. Pittock
33. Fibromyalgia and Chronic Fatigue
Gordon H Guyatt
34. Multiple Sclerosis
Julia Schaeffer, Chiara Cossetti, Giulia Mallucci, and Stefano Pluchino

Section VI. Diseases of Higher Function
35. Introduction
Joseph T. Coyle
36. Disorders of Higher Cortical Function
Anna Berti, Francesca Garbarini, and Marco Neppi-Modona
37. Disorders of Frontal Lobe Function
Peter Pressman and Howard J. Rosen
38. Stress
Bruce S. McEwen
39. Addictions
Eduardo R. Butelman, Roberto Picetti, Brian Reed, Vadim Yuferov, and Mary Jeanne Kreek
40. Sleep Disorders
Birgitte Rahbek Kornum and Emmanuel Mignot
41. Restless Legs Syndrome
Christopher Earley
42. Fear-Related Anxiety Disorders and Post-Traumatic Stress Disorder
Arshya Vahabzadeh, Charles F. Gillespie, and Kerry J. Ressler
43. Obsessive–Compulsive Disorder
Nastassja Koen and Dan J. Stein
44. Schizophrenia
Glenn T. Konopaske and Joseph T. Coyle
45. Bipolar Disorder
Heinz Grunze
46. Pain: From Neurobiology to Disease
Michael S. Gold and Miroslav Backonja
47. Migraine, David Borsook
Nasim Maleki, and Rami Burstein
48. Depression and Suicide
Maura Boldrini and J. John Mann

Section VII. Diseases of the Nervous System and Society
49. Introduction
Michael J. Zigmond
50. The Neurological and Psychiatric Consequence of Aging
Thad Polk
51. Advances in Ethics for the Neuroscience Agenda
Judy Illes and Peter B. Reiner
52. Burden of Neurological Disease
Mitchell T. Wallin and John F. Kurtzke
53. Stress, Health, and Disparities
Zinzi D. Bailey and David R. Williams
54: The impact of isolation on brain health
Richard Smeyne

Book details
ISBN: 9780323856546
Page Count: 1134
Retail Price : £155.00
9780128002445; 9780128138663; 9780123749475
Instructor Resources
Advanced students in neuroscience (molecular/cellular, behavioral, systems, cognitive, theoretical/computational, and developmental), neurobiology, neurology, and psychiatry, as well as neuroscience faculty, researchers, and postdoctoral fellows interested in becoming more involved in clinically related research