Multiscale Cell-Biomaterials Interplay in Musculoskeletal Tissue Engineering and Regenerative Medicine addresses the key concepts involved in the interactions between cells and biomaterials in the musculoskeletal tissue engineering and regenerative medicine field. The updated developments and challenges of the mechanisms/mechanobiology and structure-function properties of those interactions, as well as emerging technologies underlying tissue-engineered scaffolding, are carefully discussed. Lastly, cell engineering and cell-based therapies, growth factors/drugs properties, vascularization, immunomodulation are also outlined.
Given the large number of musculoskeletal disorders and related injuries that can affect muscles, bones and joints and lead to severe complications of the neuromuscular system, it is imperative to develop new treatment strategies to delay or repair associated diseases and to promote optimal long-term health.
Key Features
- Presents the fundamentals of the complex interplay of cells with biomaterials in musculoskeletal tissue engineering
- Includes coverage of stem cells and cell-based therapies, in vitro and in vivo models, nanotechnology, bioprinting, computational modeling, regulatory and clinical translation, and much more
- Written by global leaders in the field
Section 1: Fundamentals of cell-biomaterials interactions
1. Introduction
2. Fundamentals and mechanisms
3. Cellular signaling processes
4. Cell-protein interactions
5. The microenvironment: Recreate the ECM
6. Surface modifications – topography, porosity
7. Chemotaxis: Soluble morphogens and Growth factors
8. Cell-biomaterials: Vascularization
9. Cell-biomaterials in Immunomodulation
10. Mechanobiology regulation
11. Electrical/Magnetic stimulation
Section 2: Multiscale design, structure/function and processing technologies
12. Introduction
13. Design of polymeric biomaterials at multiscale
14. Design of Calcium phosphates cements: Structure/function
15. Biomimetic micro-/nano- scales design
16. Cells-biomaterials structure-function at different length scales
17. Computational modelling involved in multiscale design
18. Hydrogel systems design: Structure/function
19. Scaffolding design and structure/function: Electrospinning
20. Scaffolding design and structure/function: Advanced manufacturing
21. Scaffolding design and structure/function: Bioprinting
22. Dynamic models for investigating structure/function of biomaterials: Bioreactors
23. Dynamic models for investigating cell-biomaterials interactions: Microfluidics
24. Complex in vitro models for studying cell-biomaterials interactions
25. In vivo animal models 26. Regulatory and clinical translation
