The Organic Chemistry of Drug Design and Drug Action - Edition 4 - By Richard B. Silverman, Ph.D Organic Chemistry, Jose I Juncosa and Fengtian Xue Elsevier Educate

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The Organic Chemistry of Drug Design and Drug Action,

Edition 4

By Richard B. Silverman, Ph.D Organic Chemistry, Jose I Juncosa and Fengtian Xue

Publication Date: 01 Sep 2025

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The Organic Chemistry of Drug Design and Drug Action, Fourth Edition presents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action. The book's coverage allows readers to extrapolate core principles and mechanisms to many related classes of drug molecules. It reflects the significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while also including significant changes in format and coverage.

It is designed for undergraduate and graduate students in chemistry who are studying medicinal chemistry or pharmaceutical chemistry. Users, including research chemists and biochemists working in pharmaceutical and biotechnology industries will find this update to be useful in their daily work.

Key Features

Presents new figures that have been extensively updated and refreshed throughout, now in full color
Provides case studies and up-to-date examples to make the book engaging for today’s student
Includes new PowerPoint slides with clicker questions and a test bank to enhance the teaching experience

About the author

By Richard B. Silverman, Ph.D Organic Chemistry, Northwestern University, Evanston, IL, USA; Jose I Juncosa, Associate Professor Department of Chemistry Salisbury University, Salisbury, M, USA and Fengtian Xue, Associate Professor of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, USA

1. Introduction
2. Lead discovery
3. Lead modification
4. Receptors
5. Agonists and antagonists of receptors
6. Enzymes
7. Enzyme inhibition
8. DNA and RNA
9. DNA- and RNA-interactive agents
10. Other drug targets
11. Pharmacokinetics
12. Drug resistance and drug synergism
13. Prodrugs and delivery systems

ISBN: 9780443158629

Page Count: 580

Retail Price (USD) :

9780198749691; 9781496385024; 9781498702782

Undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry, Research chemists and biochemists working in pharmaceutical and biotechnology industries

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